Since green tea is hope for Down syndrome

After the recent news that scientists from the departments of basic medical sciences, neuroscience, and sense organs of the University 'of Bari and the Institute of Biomebrana and bioenergetics of the CNR of the regional capital have discovered that the genetic defects underlying primary disease mitochondrial, Down Syndrome, Parkinson's and Alzheimer's, are due to a deficit in extracting nutrients from food, Bari back to the attention of medical science always with researchers from the Institute of biomembranes and bioenergetics of the National Council of research (IBBE-CNR). Women Handbags Shop

Although more than 50 years from the identification of the genetic cause of Down syndrome (DS), a rare disease (Rare Disease), or the presence of a third copy of chromosome 21, the molecular mechanisms by which this genetic alteration produces the clinical picture of the disease are still unclear, of course you know that, in patients increases oxidative stress and is strongly impaired mitochondrial function, important determinants of cognitive deficits associated with this syndrome. Women Handbags Shop

Now, however, researchers have discovered that Bari is possible to improve this deficit with epigallocatechin-3-gallate (EGCG), a molecule of natural origin of the family of polyphenols extracted from green tea.

EGCG is commercially available, known for its anti-inflammatory and anti-tumor properties and has already been tested on humans. Women Handbags Shop

It should be emphasized, however, that the results were obtained in vitro, by treating with EGCG skin cells (fibroblasts) and the blood (lymphoblastoid, derivatives of lymphocytes), obtained from Down subjects at different stages of development.

The next steps of researchers set out to analyze the performance of bioenergy animal model before moving to the clinic to have the proof that this molecule will improve significantly the mitochondrial bioenergetic function with a selective action on cell signaling pathways affected in Down syndrome Down.

The results of the research are published in 'Biochimica et Biophysica Acta-Molecular Basis of Disease'.